Association Study of rs2987983 Polymorphism in the Promoter Region of ESR2 Gene and Susceptibility to Nodular Thyroid in Women of Markazi Province, Iran

Background: The risk of thyroid disease has been increased during recent years; more than 200 million people are suffering from various types diseases. rate nodules in women is 4 times that men. Epidemiological findings and experimental evidence lesions suggest sex hormones, especially estrogen, may affect this gland its neoplasms. Objectives: Considering the prevalence benign malignant women, we investigated association between rs2987983 polymorphism estrogen receptor beta gene nodular disease. Methods: In case-control study, 146 patients with Amir- Almomenin Hospital Arak were compared 151 healthy individuals. diagnosis was performed by ultrasonography confirmed an endocrinologist. After DNA extraction, genotyping T-ARMS PCR. Finally, statistical analysis carried out. Results: frequencies AA, AG, GG genotypes case group 48 (32.9%), 83 (56.8%), 15 (10.3%), respectively. These values control 64 (42.4%), 23 (15.2%), Overall, a statistically significant (P = 0.042, χ2 6.3, df 2) observed nodules. Conclusions: nodules, it can be suggested mentioned used as diagnostic biomarker. Because promoter region gene, probably alters expression levels.